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Sibille Lab
University of Pittsburgh
University of Pittsburgh  I  CNUP  I  TNP  I  Psychiatry  I  WPIC  I  UPMC
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The Sibille Laboratory operates within the Center for Neuroscience (CNUP) and the Translational Neuroscience Program (TNP), a program within the Department of Psychiatry at the University of Pittsburgh.

Our research efforts are primarily directed toward understanding the cellular and molecular mechanisms of major depression through translational studies in the human postmortem brain and in rodent models of the illness.

Our second research focus is directed towards understanding the molecular bases and genetic contribution of human brain aging in the development of neuropsychiatric disorders and late life function declines (health, cognition and emotionality).

Interactive Databases: Interrogate our dataset for
-Age Effect on Gene Expression in the Human Brain.             -Relative Enrichment in Cellular Transcript Level. 
           Click here to visit our Data page for more information and access to the interface.

Latest news/New Publications:
-A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. Chang LC, Jamain S, Lin CW, Rujescu D, Tseng GC, Sibille E. PLoS One. March 2014.

-Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterizations and an application guideline. Chang LC, Lin HM, Sibille E, Tseng GC. BMC Bioinformatics. 21 December 2013.

Post-Doctoral Opportunities (Employment & Fellowship)



Post-Doctoral Opportunities (Employment & Fellowship)